diff --git a/notifier/notifier.go b/notifier/notifier.go
index 78da1129a..3d2ee5949 100644
--- a/notifier/notifier.go
+++ b/notifier/notifier.go
@@ -302,12 +302,22 @@ func (n *Manager) nextBatch() []*Alert {
 // Run dispatches notifications continuously.
 func (n *Manager) Run(tsets <-chan map[string][]*targetgroup.Group) {
 	for {
+		// The select is split in two parts, such as we will first try to read
+		// new alertmanager targets if they are available, before sending new
+		// alerts.
 		select {
 		case <-n.ctx.Done():
 			return
 		case ts := <-tsets:
 			n.reload(ts)
-		case <-n.more:
+		default:
+			select {
+			case <-n.ctx.Done():
+				return
+			case ts := <-tsets:
+				n.reload(ts)
+			case <-n.more:
+			}
 		}
 		alerts := n.nextBatch()
 
diff --git a/notifier/notifier_test.go b/notifier/notifier_test.go
index 752429537..f3d7593ec 100644
--- a/notifier/notifier_test.go
+++ b/notifier/notifier_test.go
@@ -22,6 +22,7 @@ import (
 	"net/http"
 	"net/http/httptest"
 	"net/url"
+	"strconv"
 	"testing"
 	"time"
 
@@ -571,3 +572,113 @@ func makeInputTargetGroup() *targetgroup.Group {
 func TestLabelsToOpenAPILabelSet(t *testing.T) {
 	require.Equal(t, models.LabelSet{"aaa": "111", "bbb": "222"}, labelsToOpenAPILabelSet(labels.Labels{{Name: "aaa", Value: "111"}, {Name: "bbb", Value: "222"}}))
 }
+
+// TestHangingNotifier validates that targets updates happen even when there are
+// queued alerts.
+func TestHangingNotifier(t *testing.T) {
+	// Note: When targets are not updated in time, this test is flaky because go
+	// selects are not deterministic. Therefore we run 10 subtests to run into the issue.
+	for i := 0; i < 10; i++ {
+		t.Run(strconv.Itoa(i), func(t *testing.T) {
+			var (
+				done    = make(chan struct{})
+				changed = make(chan struct{})
+				syncCh  = make(chan map[string][]*targetgroup.Group)
+			)
+
+			defer func() {
+				close(done)
+			}()
+
+			// Setting up a bad server. This server hangs for 2 seconds.
+			badServer := httptest.NewServer(http.HandlerFunc(func(w http.ResponseWriter, r *http.Request) {
+				select {
+				case <-done:
+				case <-time.After(2 * time.Second):
+				}
+			}))
+			badURL, err := url.Parse(badServer.URL)
+			require.NoError(t, err)
+			badAddress := badURL.Host // Used for __name__ label in targets.
+
+			// Setting up a bad server. This server returns fast, signaling requests on
+			// by closing the changed channel.
+			goodServer := httptest.NewServer(http.HandlerFunc(func(w http.ResponseWriter, r *http.Request) {
+				close(changed)
+			}))
+			goodURL, err := url.Parse(goodServer.URL)
+			require.NoError(t, err)
+			goodAddress := goodURL.Host // Used for __name__ label in targets.
+
+			h := NewManager(
+				&Options{
+					QueueCapacity: 20 * maxBatchSize,
+				},
+				nil,
+			)
+
+			h.alertmanagers = make(map[string]*alertmanagerSet)
+
+			am1Cfg := config.DefaultAlertmanagerConfig
+			am1Cfg.Timeout = model.Duration(200 * time.Millisecond)
+
+			h.alertmanagers["config-0"] = &alertmanagerSet{
+				ams:     []alertmanager{},
+				cfg:     &am1Cfg,
+				metrics: h.metrics,
+			}
+			go h.Run(syncCh)
+			defer h.Stop()
+
+			var alerts []*Alert
+			for i := range make([]struct{}, 20*maxBatchSize) {
+				alerts = append(alerts, &Alert{
+					Labels: labels.FromStrings("alertname", fmt.Sprintf("%d", i)),
+				})
+			}
+
+			// Injecting the hanging server URL.
+			syncCh <- map[string][]*targetgroup.Group{
+				"config-0": {
+					{
+						Targets: []model.LabelSet{
+							{
+								model.AddressLabel: model.LabelValue(badAddress),
+							},
+						},
+					},
+				},
+			}
+
+			// Queing alerts.
+			h.Send(alerts...)
+
+			// Updating with a working alertmanager target.
+			go func() {
+				select {
+				case syncCh <- map[string][]*targetgroup.Group{
+					"config-0": {
+						{
+							Targets: []model.LabelSet{
+								{
+									model.AddressLabel: model.LabelValue(goodAddress),
+								},
+							},
+						},
+					},
+				}:
+				case <-done:
+				}
+			}()
+
+			select {
+			case <-time.After(300 * time.Millisecond):
+				t.Fatalf("Timeout after 300 milliseconds, targets not synced in time.")
+			case <-changed:
+				// The good server has been hit in less than 3 seconds, therefore
+				// targets have been updated before a second call could be made to the
+				// bad server.
+			}
+		})
+	}
+}