diff --git a/config.h.in b/config.h.in
index 0c3342f2..21fb74cd 100644
--- a/config.h.in
+++ b/config.h.in
@@ -101,6 +101,17 @@
 /* compile the zip archive support */
 #undef WITH_ZIP_ARCHIVE
 
+/* Enable large inode numbers on Mac OS X 10.5.  */
+#ifndef _DARWIN_USE_64_BIT_INODE
+# define _DARWIN_USE_64_BIT_INODE 1
+#endif
+
+/* Number of bits in a file offset, on hosts where this is settable. */
+#undef _FILE_OFFSET_BITS
+
+/* Define for large files, on AIX-style hosts. */
+#undef _LARGE_FILES
+
 /* Define to 1 if on MINIX. */
 #undef _MINIX
 
diff --git a/configure.ac b/configure.ac
index 33e8d2c0..5192bbca 100644
--- a/configure.ac
+++ b/configure.ac
@@ -225,6 +225,9 @@ if test x$HAS_EM_TILEGX = xyes; then
             [Defined to 1 if elf.h has EM_TILEGX macro defined])
 fi
 
+dnl Set large files support
+AC_SYS_LARGEFILE
+
 AC_CONFIG_FILES([Makefile
 libabigail.pc
   include/Makefile