diff --git a/.github/matrix.py b/.github/matrix.py
index d3ab890dad..a9ab4424ec 100755
--- a/.github/matrix.py
+++ b/.github/matrix.py
@@ -123,8 +123,8 @@ def main(ref_name):
                     "OT_INC=${HOME}/opt-ot/include",
                     "OT_LIB=${HOME}/opt-ot/lib",
                     "OT_RUNPATH=1",
-                    "USE_PCRE=1",
-                    "USE_PCRE_JIT=1",
+                    "USE_PCRE2=1",
+                    "USE_PCRE2_JIT=1",
                     "USE_LUA=1",
                     "USE_OPENSSL=1",
                     "USE_SYSTEMD=1",
@@ -157,8 +157,8 @@ def main(ref_name):
                     "OT_INC=${HOME}/opt-ot/include",
                     "OT_LIB=${HOME}/opt-ot/lib",
                     "OT_RUNPATH=1",
-                    "USE_PCRE=1",
-                    "USE_PCRE_JIT=1",
+                    "USE_PCRE2=1",
+                    "USE_PCRE2_JIT=1",
                     "USE_LUA=1",
                     "USE_OPENSSL=1",
                     "USE_SYSTEMD=1",